Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents.
نویسندگان
چکیده
We report the design and synthesis of a series of non-nucleoside MtbTMPK inhibitors (1-14) based on the gram-positive bacterial TMPK inhibitor hit compound 1. A practical synthesis was developed to access these analogues. Several compounds show promising MtbTMPK inhibitory potency and allow the establishment of a structure-activity relationship, which is helpful for further optimization.
منابع مشابه
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عنوان ژورنال:
- Bioorganic & medicinal chemistry
دوره 24 21 شماره
صفحات -
تاریخ انتشار 2016